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Basic Research Journal of Medicine and Clinical Sciences ISSN 2315-6864 Vol. 6(6): Pp 59-66 June 2017

Copyright© 2017 Basic Research Journals

International Scientific Indexing lSI Impact Factor (0.836)


Full Length Research Paper


T2 Mapping issues of the knee articular cartilage at 3 Tesla


*Mokhtar Mars1, Mouna Bouaziz2, Zeineb Tbini1, Fethi Ladab2, Souha Gharbi1


1Université Tunis EL Manar, Institut Supérieur des Technologies Médicales de Tunis, Laboratoire de recherche de Biophysique et de Technologies Médicales, 9, Avenue du Docteur Z. Essafi, 1006 Tunis, Tunisia.

2Service de Radiologie, Institut Kassab d’orthopédie, Ksar Saïd, Tunisie, 2010 Ksar Said, Tunisia.


*Corresponding author email: mokhtar.mars@mms.tn


Received 30 June, 2017; Accepted 16 July, 2016; 08 August, 2017




Background: Early identification of Knee Osteoarthritis (OA) is important to improve clinical decision making. MRI T2 mapping sequences were used to detect biochemical changes which happen in early stage of OA. This study was aims to compare the mean T2 relaxation time values, Signal to Noise Ratio (SNR) and Contrast between spin echo family sequences used in the evaluation of the knee articular cartilage. Materials and Methods: Thirty one subjects underwent a femoral-tibial articular knee cartilage exam at 3 Tesla Magnetic Resonance Imaging (MRI). We compared mean T2 Values, SNR and contrast between Single Echo Spin Echo (SESE), Multi Echo Spin Echo (MESE) and Fast Spin Echo (FSE) sequences. Results: The results showed a T2 average values equal to 46.6 ± 15.6% for the SEME, 40.5 ± 13.3% for SESE and 42.9± 13.8% for FSE. The SESE had the best fitting factor with R2min = 0.999 followed by the FSE with R2min = 0.995 and MESE with R2min = 0.962. Regarding SNR, MESE and FSE showed higher SNR in most regions compared to the SESE. MESE gave the best cartilage and bone contrast followed by the FSE and SESE. The comparison of the reference SESE sequence with other sequences using the Pearson test showed significant difference in most regions (p <0.05). Conclusions:  We conclude there is a variation of mean T2 values, fitting, contrast and signal to noise ratio between sequences. Difference between sequences types and parameters lead to variation of T2 relaxation time. Care must be taken when performing T2 mapping and interpreting results.


Keywords: Cartilage, Osteoarthritis, T2 mapping, MRI sequence


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